Preheat the oven to 375 degrees F and line a baking sheet with parchment paper. Lightly flour the parchment paper.
In a large bowl add flour, onion powder, garlic powder, baking powder and salt. Whisk together until combined.
In a medium bowl add cottage cheese, cheddar cheese, eggs, ham, and chives. Mix until fully combined.
Add cottage cheese mixture to the large bowl with dry ingredients and mix with a wooden spoon or silicone spatula. When the dough begins to form switch to using clean floured hands to mix the dough and form a large dough ball. Add a sprinkle of flour when needed if the dough is too sticky to work with. Note: dough will be slightly sticky, but should be able to form into a ball.
Place dough ball on the lined baking sheet and flatten dough with your hands to form a large rectangle, roughly 7” by 10” (does not need to be perfect!).
Using a knife or bench scraper, divide the dough into 12 equal biscuits. Space the biscuits apart evenly on the baking sheet.
Bake biscuits for 22-25 minutes until tops are slightly golden brown and bottom of biscuits are golden brown. Allow to cool slightly before serving.
Enjoy as is or slice in half and use for breakfast sandwiches.